Medicus curat Natura Sanat

Doctor treats, nature heals

Our mission is to support patients with neoplastic & other chronic illnesses on their healing journey with the best of our heart, knowledge and decades of experience. Our innovative, unique and individualized therapy concept is based on immunotherapy combined with hyperthermia treatments in an integrated therapy approach.

Dr. Ralf Kleef

Dr. Ralf Kleef

A leading expert in immunotherapy with experience spanning decades.

Read the message from the founder

Contact us for consultation

Request an initial Skype consultation with Dr. Kleef. Give us your phone number or Skype name if you would like us to speak to you live first before scheduling a consultation. Otherwise, we will contact you by email.
Please note that we can call you during our office hours: M to F: 9 am – 5 pm (GMT+2).

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Meet the doctor and founder

Dr. Ralf Kleef is a well-known and acclaimed medical and naturopathic doctor specialized in Immunotherapy & Hyperthermia for patients with neoplastic & other chronic illnesses. With his training in immunology in Germany and at Memorial Sloan Kettering Cancer Centre in NYC and later at the NIH, Office of Alternative Medicine (OAM), in 1996 he found his passion: treating cancer through immunotherapy in the footsteps of the father of cancer immunotherapy, William B. Coley.

He founded his Insitute for Hyperthermia and Immunotherapy 1998 in Vienna and treated more than 20,000 patients over the last three decades. His journey goes on with expanding his center to Budapest, Hungary.

Our unique therapy concept

Immunotherapy treatment combined with Hyperthermia.

Dr. Kleef invented a unique cancer treatment concept: immunotherapy combined with hyperthermia and complementary medicine in an integrative approach which is personalized for each and every patient to support the patient´s immune system to fight the illness.

We believe that this is a safe protocol, which is easily tolerable for patients. In our treatments, the side effects of immunotherapy (immune-related adverse effects) occur in much lesser degrees of intensity. Perfecting his approach over the last years, he was able to improve the effectiveness of treatment to a considerable extent.

Discover our combined individualized diagnosis and therapy concept

Dr. Kleef creates individualized therapy plans, specific for every patient’s needs using the following methods:

Diagnosis

Diagnoses comes first!

Immunotherapy

Empowering your immune system with the latest advances in the field

Whole body hyperthermia

Fever-range WBH supports any immunotherapy, CHT or radiation

Loco-regional hyperthermia

Cancer cells don’t like heat: targeting cancer locally

Chemotherapy

A classical method based on chemosensitivity testing and often metronomic (lower dosages)

Ozone therapy

Oxygen to recover all cells


High-dose Vitamin C

A unique combination: our versatile everyday vitamin is combined with alpha lipoic acid

Mistletoe Therapy

100 year old Anthroposophy wisdom to support the immune system

FMT

Rejuvenate your intestinal microbiome


Our 30 years of experience

Dr. Ralf Kleef MD, ND, the founder and Chief Medical Director navigates the Clinic since 1998 in research, development and application of innovative cancer therapies.

Outstanding expertise

Dr. Kleef has gained more than 30 years of experience in the field of integrative oncology

Outstanding expertise

Dr. Kleef has gained more than 30 years of experience in the field of integrative oncology
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Qualified team

Our team members are well trained, experienced and full-hearted expert staff, who are dedicated to give the best care to each and every patient

Qualified Team

Our team members are well trained, experienced and full-hearted expert staff, who are dedicated to give the best care to each and every patient

Therapeutic results

More than 20,000 patients have trusted our care

Therapeutic results

More than 20,000 patients have trusted our care
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Top quality devices

Most advanced medical devices – with quality guarantee

Top quality devices ​

Most advanced medical devices – with quality quarantee

Numerous scientific publications

Peer reviewed published papers, case studies, presentations at renowned conferences

Numerous scientific publications

Peer reviewed published papers, case studies, presentations at renowned conferences
Learn more

Worldwide network

Established connections to renowned institutions, doctors and experts all around the world

Worldwide network

Established connections to renowned institutions, doctors and experts all around the world

Patient testimonials

We feel blessed to present you our exceptional patients who believed in themselves, focused on healing and entrusted our care to support them on their healing journey.

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It was a painful process, but it worked perfectly. The tumor disappeared. I still have my larynx today and can speak practically normal. I am very grateful to Dr. Kleef and his team! I am healthy!
Michael Silva Kutalek
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Stepping into Dr. Kleef’s office was like entering a spa. After being labeled as a number for months I finally was treated like a human being.

Diana Wright
Terry Mah copy
Finding Dr. Kleef and combining his treatments with our own methodologies of BodyTalk and mind work, means that I am here rounding the corner of 5 years of surviving a terminal diagnosis.
Terri Mah
woman
Overcoming cancer is never easy, but it doesn't have to be the worst time of your life. If you choose to receive care from Dr. Kleef and his staff, you are choosing a path of healing and holistic care.
Anna Carlini
man
The early results that the treatment is working and I am on the road to recovery, it will be difficult journey back to full health but to know that I’m on the right path is half the battle.
Leon Brennan
man
Dr. Kleef was recommended by several long term stage IV survivors we had gotten in touch with and some of the best integrative oncologists in the US. The results have been astonishing.
David Ashville
man2
They have all the standard treatments found in all good cancer clinics but their most effective treatments are only available here. Dr. Kleef (a great guy) is a titan among oncologists and has a very professional, friendly staff.
Jeffrey Hall
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I’m very grateful to Dr. Kleef and his wonderful staff. The treatment was tough, but they made it as good as possible. I’ve been home 6 weeks and am feeling better than I’ve felt in a very long time.
Shane Fishbein
Elena Gallenberger
I remain in remission from my stage III breast cancer. Dr. Kleef's clinic has kept in touch with me and has been responsive to any questions I had after I got home and over the past four years. I would definitely recommend Dr. Kleef to others seeking integrative cancer treatment.
Elena Gallenberger

The process we follow

Throughout the whole process, from your initial contact, through treatment and after you leave our clinic, our patient coordinators will guide you through the steps and support you with all their expertise, attention and kindness.

1
First inquiry

We will ask you to fill in our medical evaluation and data consent sheet, furthermore to provide us with all your relevant medical records.
2
Skype consultation with Dr. Kleef
You will be scheduled for a detailed consultation about your case including medical history, recent findings and specific therapeutic recommendations.
3
Therapy plan & cost estimate
Your personal patient coordinator will provide you your personalized preliminary treatment plan and you will also receive the associated cost breakdown.
4
Confirmation for treatment
After confirmation your personal patient coordinator will inform & support you about all the steps and arrangements to be taken prior to arrival to our Clinic.

We will help with your questions!